The
Histidine Protein Kinases Reference Page
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Classification
of Histidine Protein Kinases and Their Cognate Response Regulators Links to
Other Web-Sites Related to Two-Component Signaling Design by TWG
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Histidine Protein Kinases (HPKs) constitute a large family of sensory proteins. They are employed by prokaryotes, archaea, and to some extent by eukaryotes to sense internal as well as external stimuli. HPKs convey sensory information to so called response regulators (RRs) by means of phosphorylation. Upon phosphorylation RRs modulate enzymatic activities, cell cycle regulation, expression of antibiotic resistance, chemotactic movement, fruit ripening and many other very diverse physiological processes (see table) . More than 500 sequences of histidine protein kinases have been deposited in public databases since their first identification in the late 1980ies.
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