H.Scherthan, selected publications
Scherthan H, Geiger
B, Ridinger D, Müller J, Riccobono D, Bestvater F, Port
M and Hausmann M. (2023) Nano-Architecture of Persistent Focal DNA Damage
Regions in the Minipig Epidermis Weeks after Acute γ-Irradiation. Biomolecules 13(10), 1518; https://doi.org/10.3390/biom13101518
PDF
Scherthan H, Wagner
S-Q, Grundhöfer J, Matejka
N, Müller J, Müller S, Rudigkeit S, Sammer M, Schoof S, Port M, Reindl J. (2022) Planar Proton Minibeam Irradiation Elicits
Spatially Confined DNA Damage in a Human Epidermis Model. Cancers 14, 1545. https://doi.org/10.3390/cancers14061545. PDF
Ullmann R, Becker BV,
Rothmiller S, Schmidt A, Thiermann
H, Kaatsch HL, Schrock G, Müller J, Jakobi J, Obermair R, Port M,
Scherthan H. (2021) Genomic Adaption and Mutational Patterns in a HaCaT Subline
Resistant to Alkylating Agents and Ionizing Radiation. Int J Mol Sci. 22(3):1146. PDF
Muhtadi R, Lorenz
A, Mpaulo SJ, Siebenwirth C, Scherthan H. (2020)
Catalase T-Deficient Fission Yeast Meiocytes Show Resistance to Ionizing
Radiation. Antioxidants (Basel). 9(9):E881. PDF
Scherthan H, Lee
JH, Maus E, Schumann S, Muhtadi R, Chojowski R, Port M, Lassmann M, Bestvater F, Hausmann M.
(2019) Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution
Irradiation with the Alpha Emitter Ra-223. Cancers
11(12). pii: E1877. PDF
Ahmed
EA, Rosemann M, Scherthan H. (2018) NHEJ Contributes to the Fast Repair of
Radiation-induced DNA Double-strand Breaks at Late Prophase I Telomeres. Health
Physics, 115:102-107 request PDF
Hausmann M, Wagner
E, Lee J-H, Schrock G, Schafler W, Krufczik M, Papenfuß F, Port M,
Bestvater F and Scherthan H. (2018) Super-Resolution Localization Microscopy of
Radiation-Induced Histone H2AX-Phosphorylation in relation to
H3K9-Trimethylation in HeLa Cells. Nanoscale
10:4320-4331 request PDF
Schumann S, Eberlein
U, Muhtadi R, Lassmann M, Scherthan H. (2018) DNA damage in leukocytes after
internal ex-vivo irradiation of blood with the α-emitter Ra-223. Sci Reports 8(1):2286. doi:
10.1038/s41598-018-20364-7. PDF
Styllou P, Styllou M, Hickel R, Högg C, Reichl FX, Scherthan H.
(2017) NAC ameliorates dental composite-induced DNA double-strand breaks and
chromatin condensation. Dent Mater J.
doi: 10.4012/dmj.2016-316. PDF
Muhtadi R., Ahmed
E.A., Scherthan H. (2017) Spermatocyte Spreading during Meiotic Cell
Preparation is a Two Step Process. Journal of Cytology & Histology 8:2
DOI: 10.4172/2157-7099.1000450 PDF
Scherthan H. (2017)
Imaging of Chromosome Dynamics in Mouse Testis Tissue by Immuno-FISH. Methods Mol Biol.
1471:231-243. request PDF
Illner D., Lorenz
A., Scherthan H. (2016) Meiotic chromosome mobility in fission yeast is resistant
to environmental stress. Scientific
Reports 6:24222. PDF
Scherthan H, Sotnik N, Peper M, Schrock G, Azizova
T, Abend M. (2016) Telomere Length in Aged Mayak PA
Nuclear Workers Chronically Exposed to Internal Alpha and External Gamma
Radiation. Radiat Res. 185(6):658-67. request PDF
Eberlein U, Peper
M, Fernández M, Lassmann M, and Scherthan H. (2015)
Calibration of the γH2AX DNA Double Strand Break
Focus Assay for Internal Radiation Exposure of Blood Lymphocytes. PLoS One 10(4): e0123174. PDF
Scherthan H,
Schöfisch K, Dell T, Illner D. (2014) Contrasting behavior of heterochromatic
and euchromatic chromosome portions and pericentric genome separation in
pre-bouquet spermatocytes of hybrid mice. Chromosoma,
123:609-24. PDF
Lamkowski A, Forcheron F, Agay D, Ahmed EA, Drouet M, Meineke V and Scherthan H. (2014) DNA Damage
Focus Analysis in Blood Samples of Minipigs Reveals Acute Partial Body
Irradiation. PLoS One 9(2): e87458. PDF
Illner D and
Scherthan H (2013) Ionizing irradiation-induced radical stress stalls live
meiotic chromosome movements by altering the actin cytoskeleton. Proc Natl Acad Sci USA. 110:16027-32. PDF
Ahmed EA, Sfeir A, Takai H and Scherthan H
(2013) Ku70 and non-homologous end joining protect testicular cells from DNA
damage. J Cell Sci. 126, 3095–3104. PDF
Ahmed EA, Agay D, Schrock, G, Drouet M,
Meineke V and Scherthan H. (2012) Persistent DNA damage after high dose in vivo gamma exposure of minipig skin. PLoS One; 7(6): e39521. PDF
Scherthan, H.
(2012) Chromosome numbers in Mammals. In: Encyclopedia
of Life Sciences. www.els.net. doi.org/10.1002/9780470015902.a0005799.pub3
Link
Adelfalk C, Ahmed
EA and Scherthan H. (2011) Reproductive phenotypes of mouse models illuminate
human infertility. J. Reprod
Medicine & Endocrinol. 8: 376-383. PDF Review
Scherthan
H. and Adelfalk C. (2011) Live cell imaging of budding yeast.
Methods Molec. Biol. 745:537-48. request PDF
Scherthan H, Sfeir
A, de Lange T. (2011) Rap1-independent telomere attachment and bouquet
formation in mammalian meiosis. Chromosoma 120:151-7. PDF
Muradyan A, Gilbertz K, Stabentheiner S, Klause S, Madle H, Meineke V, Ullmann R and Scherthan H. (2011) Acute
High-Dose X-Radiation-Induced Genomic Changes in A549 Cells. Radiat Res. 175:700-770. request PDF
Lassmann M., Hänscheid H., Gassen D., Biko J.,
Meineke V., Reiners C. and Scherthan H. (2010)
In-vivo gamma-H2AX and 53BP1 focus formation in blood cells after radioiodine
therapy of differentiated thyroid cancer. J Nuclear Medicine 51:1318-25.
PDF
Adelfalk C., Janschek J., Revenkova E., Liebe
B., Göb E., Alsheimer M, Benavente R., de Boer E, Novak I, Höög
C, Scherthan H. and Jessberger R. (2009) Cohesin
SMC1ß protects telomeres in meiocytes. J. Cell Biol., 187:185-99 PDF
Erenpreisa J, Cragg MS, Salmina K , Hausmann M,
Scherthan H (2009) The role of meiotic cohesin REC8 in chromosome segregation
in gamma irradiation-induced endopolyploid tumour
cells. Exp. Cell Res., 315:2593-2603 PDF
Scherthan H, Hieber L, Braselmann H, Meineke
V, Zitzelsberger H. (2008) Accumulation of DSBs in
gamma-H2AX domains fuel chromosomal aberrations. Biochem
Biophys Res Commun.
371: 694-7. request PDF
Scherthan H, Wang H, Adelfalk C, White EJ, Cowan C, Cande WZ, and Kaback DB (2007) Chromosome mobility during meiotic prophase in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA, 104:16934-16939. PDF
Scherthan H., Abend M., Müller K., Beinke C., Braselmann H., et al. (2007) Radiation-induced late
effects in two affected individuals of the Lilo
radiation accident. Radiation Res., 167:615-623. request PDF
Scherthan, H.
(2007) Telomere attachment and clustering during meiosis. Cell. Mol. Life
Sci. 64:117-124. request PDF
Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano
T, Pandita TK, Jasin M, Fornace
A, Meistrich ML, Baarends
WM, Schimenti J, de Lange T, Keeney S, Camerini-Otero RD & Scherthan H. (2006) Mutations that
affect meiosis in male mice influence the dynamics of the mid-preleptotene and
bouquet stages. Exp. Cell Res. 312: 3768-3781. request PDF
Scherthan
H. (2006) Factors directing telomere dynamics in synaptic meiosis. Biochem Soc Trans.
34:550-553. PDF
Trelles-Sticken E.,
Adelfalk C., Loidl J. and Scherthan H. (2005) Meiotic telomere clustering
requires actin for its formation and cohesin for its resolution. J Cell Biol.,
170:213-223. PDF
Hartmann N. and
Scherthan H. (2005) Characterization of the telomere complex, TERF1 and TERF2
genes in muntjac species with fusion karyotypes. Exp. Cell Res.
306:64-74. request PDF
Loidl J. and Scherthan
H. (2004) Organization and pairing of meiotic chromosomes in the ciliate Tetrahymena
thermophila. J Cell Sci. 117:5791-5801. PDF
Roig I., Liebe B., Egozcue J., Cabero L, Garcia M.,
and Scherthan H. (2004) Female-specific features of recombinational
double-stranded DNA repair in relation to synapsis and telomere dynamics in
human oocytes. Chromosoma 113:22-33. request
PDF
Revenkova E., Eijpe M., Heyting C., Hodges
C.A., Hunt P.A., Liebe B., Scherthan H. & Jessberger
R. (2004) SMC1b is required for meiotic chromosome dynamics, sister chromatid
cohesion, and DNA recombination. Nat. Cell Biol. 6:555-562.
Hartmann N. and Scherthan
H. (2004) Characterization of ancestral chromosome fusion points in the Indian
muntjac deer. Chromosoma 112:213-20. request
PDF
Liebe B., Alsheimer M., Hoog C., Benavente R., Scherthan H. (2004) Telomere attachment,
meiotic chromosome condensation, pairing and bouquet stage duration are
modified in spermatocytes lacking axial elements. Molec.
Biol. Cell, 15:827-837.
Scherthan, H.
(2004) Interphase cytogenetics in understanding chromosome and telomere dynamics
during prophase I: implications for meiotic telomere movements. In: Chromosomes
Today (Schmid M. and
Scherthan, H.
(2003) Knockout mice provide novel insights into meiotic chromosome and
telomere dynamics. Cytog. Genome Res.
103: 235-44. (Erratum
in: Cytog. Genome Res. 2005;108:364-5) request PDF
Voet, T., Liebe, B., Labaere C., Marynen P., and
Scherthan H. (2003) Telomere-independent homologue pairing and checkpoint
escape of accessory ring chromosomes in male mouse meiosis. J. Cell Biol.,
162:795-808.
Pfeifer C.,
Scherthan H. and Thomsen P.D. (2003) Sex-specific telomere redistribution and
synapsis initiation in cattle oogenesis. Dev. Biol., 255:206-215. PDF
Neale M.J.,
Ramachandran M., Trelles-Sticken E., Scherthan H. and Goldman A.S.H. (2002)
Wild-type levels of Spo11-induced DSBs are required for normal single-strand
resection during meiosis. Mol. Cell 9:835-846.
Weiss, H and
Scherthan H. (2002) Aloe ssp.- plants with vertebrate-like telomeric sequences.
Chromos. Res. 10:155-164. request PDF
Scherthan H. (2001)
A bouquet makes ends meet. Nature Rev. Mol. Cell Biol., 2:621-627. request PDF
Pfeifer C, Thomsen
PD, and Scherthan H. (2001) Centromere and telomere redistribution precedes
homologue pairing and terminal synapsis initiation during prophase I of cattle
spermatogenesis. Cytogenet Cell Genet.,
93:304-314.
Trelles-Sticken E.,
Dresser M.E., and Scherthan H. (2000) Meiotic telomere protein Ndj1p is
required for meiosis specific telomere distribution, bouquet formation and
efficient homologue pairing. J. Cell Biol., 151: 95-106
Scherthan H., Jerratsch M., Li B., Smith S., Hulten
M., Lock T., and de Lange T. (2000) Mammalian meiotic telomeres: protein
composition and their redistribution in relation to nuclear pores. Mol. Biol. Cell 11:4189-4203. PDF
Pandita T.K., Westphal C.H., Anger M., Sawant
S.G., Geard C.R., Pandita R.K., and Scherthan H.
(1999) Atm inactivation results in aberrant telomere clustering during meiotic
prophase. Mol. Cell. Biol. 19: 5096-5105.
Meyer-Ficca M., Muller-Navia J. and
Scherthan H. (1998) Clustering of pericentromeres initiates in step 9 of
spermiogenesis of the rat (Rattus norvegicus) and contributes to a well-defined genome
architecture in the sperm nucleus. J.
Cell Sci. 111:1363-1370. PDF
Scherthan H. (1997)
Chromosome behaviour in earliest meiotic prophase.
In: Chromosomes Today Vol. 12 (H.Gill, J.S. Parker, M. Puertas
eds.), Chapman and Hall,
Scherthan H., Weich S., Schwegler H., Heyting C., Harle M. and Cremer T
(1996) Centromere and telomere movements during early meiotic prophase of mouse
and man are associated with the onset of chromosome pairing. J. Cell Biol. 134:1109-1125. PDF
Scherthan H., Bahler J. and Kohli J. (1994)
Dynamics of chromosome organization and pairing during meiotic prophase in
fission yeast. J. Cell Biol. 127:
273-285. PDF
Scherthan H.,
Cremer T.,
Scherthan H., Schweizer D. and Loidl J. (1993) Delineation of individual
chromosomes of Saccharomyces cerevisiae
by two colour in situ hybridisation.
Trends Genetics 9:41. PDF
Scherthan H, Loidl
J, Schuster T, Schweizer D. (1992) Meiotic chromosome
condensation and pairing in Saccharomyces
cerevisiae studied by chromosome painting. Chromosoma. 101:590-5. request PDF
Scherthan H.,
Kohler M., Vogt P., von Malsch K. and Schweizer D. (1992) Non isotopic chromosomal in situ hybridisation with double labelled DNA: signal
amplification at the probe level. Cytogenet. Cell Genet.
60:4-7.
Scherthan H. (1991)
Characterisation of a tandem repetitive sequence
cloned from the deer Capreolus capreolus and its chromosomal localisation in two muntjac species. Hereditas. 115(1):43-9. PDF
Scherthan H. (1990)
Localization of the repetitive telomeric sequence (TTAGGG)n in two muntjac
species and implications for their karyotypic evolution. Cytogenet. Cell Genet. 53:115-117.
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